(this has been moved from the SEASON 4 section to here. Please contimue commenting - thanks!)
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Question: Any major character deaths on Lost this season? — Sophie
Ausiello: None that I know of, but, after screening the first two eps, it certainly looks like a female cast-member isn’t long for this world. The fact that she was recently cast in a big Hollywood movie doesn’t bode well either. (Doc Jensen’s got more on Lost’s Jan. 21 premiere!)
source :
http://ausiellofiles.ew.com
It's been said that it will be Charlotte who will die in EP 5.01/5.02